{"id":"brd2","type":"gene","name_en":"BRD2 (bromodomain containing 2)","name_zh":"BRD2（含溴结构域蛋白 2）","aliases":["BRD2","bromodomain containing 2"],"description":{"en":"In patient-derived xenograft models, PTEN loss recruited BRD2 to MES gene promoters; genetic ablation of BRD2 bromodomains reversed the MES transition and increased radiation sensitivity.","zh":"在患者来源异种移植模型中，PTEN 缺失使 BRD2 被招募至 MES 基因启动子；基因敲除 BRD2 溴结构域可逆转 MES 转变并提高放射敏感性。"},"externalIds":{"hgnc_symbol":"BRD2","hgnc_id":"HGNC:1103","uniprot":"P25440"},"graphNames":["BRD2"],"mentions":{"items":["VC0095"],"topics":["cell-state-mes-like","transition-therapy-induced-plasticity"]},"evidenceRefs":["VC0095"],"reviewStatus":"draft","version":"0.1.0","page_url":"https://gliostate.com/entities/brd2/","page_url_zh":"https://gliostate.com/zh/entities/brd2/","api_url":"https://gliostate.com/api/entities/brd2.json","external_links":[{"scheme":"HGNC","id":"HGNC:1103","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:1103"},{"scheme":"UniProt","id":"P25440","url":"https://www.uniprot.org/uniprotkb/P25440/entry"}],"source_file":"https://gliostate.com/data/entities/brd2.json","evidence_items":[{"id":"VC0095","title":"BRD2 bromodomain-mediated regulation of cell state plasticity modulates therapy response in glioblastoma.","year":"2025","page_url":"https://gliostate.com/library/VC0095/","api_url":"https://gliostate.com/api/items/VC0095.json"}],"mentioned_in_items":[{"id":"VC0095","title":"BRD2 bromodomain-mediated regulation of cell state plasticity modulates therapy response in glioblastoma.","year":"2025","page_url":"https://gliostate.com/library/VC0095/","api_url":"https://gliostate.com/api/items/VC0095.json"}],"mentioned_in_topics":[{"id":"cell-state-mes-like","title_en":"Mesenchymal-like (MES-like) glioblastoma cell state","title_zh":"胶质母细胞瘤间充质样（MES 样）细胞状态","url":"https://gliostate.com/cell-states/mesenchymal-like/","api_url":"https://gliostate.com/api/topics/cell-state-mes-like.json"},{"id":"transition-therapy-induced-plasticity","title_en":"Therapy-induced plasticity in glioblastoma","title_zh":"胶质母细胞瘤的治疗诱导可塑性","url":"https://gliostate.com/transitions/therapy-induced-plasticity/","api_url":"https://gliostate.com/api/topics/transition-therapy-induced-plasticity.json"}],"relations":[{"subject":"brd2","subject_name_en":"BRD2 (bromodomain containing 2)","subject_name_zh":"BRD2（含溴结构域蛋白 2）","predicate":"promotes","object":"mes-like-state","object_name_en":"Mesenchymal-like (MES-like) state","object_name_zh":"间充质样（MES 样）状态","confidence":"high","evidence":[{"id":"VC0095","role":"supports","title":"BRD2 bromodomain-mediated regulation of cell state plasticity modulates therapy response in glioblastoma.","page_url":"https://gliostate.com/library/VC0095/","api_url":"https://gliostate.com/api/items/VC0095.json"}],"note":{"en":"Evidence is from patient-derived xenograft and cell models: PTEN loss recruited BRD2 to MES gene promoters and bromodomain ablation reversed the MES transition.","zh":"证据来自患者来源异种移植与细胞模型：PTEN 缺失使 BRD2 被招募至 MES 基因启动子，溴结构域敲除逆转 MES 转变。"},"sources":[{"kind":"topic","id":"cell-state-mes-like","url":"https://gliostate.com/cell-states/mesenchymal-like/","api_url":"https://gliostate.com/api/topics/cell-state-mes-like.json"},{"kind":"topic","id":"transition-therapy-induced-plasticity","url":"https://gliostate.com/transitions/therapy-induced-plasticity/","api_url":"https://gliostate.com/api/topics/transition-therapy-induced-plasticity.json"}]},{"subject":"brd2","subject_name_en":"BRD2 (bromodomain containing 2)","subject_name_zh":"BRD2（含溴结构域蛋白 2）","predicate":"validated_by","object":"pdx-model","object_name_en":"Patient-derived xenograft (PDX) models","object_name_zh":"患者来源异种移植（PDX）模型","confidence":"high","evidence":[{"id":"VC0095","role":"supports","title":"BRD2 bromodomain-mediated regulation of cell state plasticity modulates therapy response in glioblastoma.","page_url":"https://gliostate.com/library/VC0095/","api_url":"https://gliostate.com/api/items/VC0095.json"}],"note":{"en":"Tested in patient-derived xenografts; not shown in patients.","zh":"在患者来源异种移植中检验；尚未在患者中证实。"},"sources":[{"kind":"topic","id":"cell-state-mes-like","url":"https://gliostate.com/cell-states/mesenchymal-like/","api_url":"https://gliostate.com/api/topics/cell-state-mes-like.json"}]},{"subject":"brd2","subject_name_en":"BRD2 (bromodomain containing 2)","subject_name_zh":"BRD2（含溴结构域蛋白 2）","predicate":"associated_with","object":"radiotherapy","object_name_en":"Radiotherapy","object_name_zh":"放射治疗","confidence":"medium","evidence":[{"id":"VC0095","role":"supports","title":"BRD2 bromodomain-mediated regulation of cell state plasticity modulates therapy response in glioblastoma.","page_url":"https://gliostate.com/library/VC0095/","api_url":"https://gliostate.com/api/items/VC0095.json"}],"note":{"en":"Genetic ablation of BRD2 bromodomains increased radiation sensitivity in xenografts.","zh":"在异种移植中，基因敲除 BRD2 溴结构域提高了放射敏感性。"},"sources":[{"kind":"topic","id":"cell-state-mes-like","url":"https://gliostate.com/cell-states/mesenchymal-like/","api_url":"https://gliostate.com/api/topics/cell-state-mes-like.json"}]}],"related_entities":[{"id":"mes-like-state","type":"cell_state","name_en":"Mesenchymal-like (MES-like) state","name_zh":"间充质样（MES 样）状态","page_url":"https://gliostate.com/entities/mes-like-state/","page_url_zh":"https://gliostate.com/zh/entities/mes-like-state/","api_url":"https://gliostate.com/api/entities/mes-like-state.json","via":"relation"},{"id":"pdx-model","type":"model","name_en":"Patient-derived xenograft (PDX) models","name_zh":"患者来源异种移植（PDX）模型","page_url":"https://gliostate.com/entities/pdx-model/","page_url_zh":"https://gliostate.com/zh/entities/pdx-model/","api_url":"https://gliostate.com/api/entities/pdx-model.json","via":"relation"},{"id":"radiotherapy","type":"method","name_en":"Radiotherapy","name_zh":"放射治疗","page_url":"https://gliostate.com/entities/radiotherapy/","page_url_zh":"https://gliostate.com/zh/entities/radiotherapy/","api_url":"https://gliostate.com/api/entities/radiotherapy.json","via":"relation"},{"id":"glioblastoma","type":"disease","name_en":"Glioblastoma (GBM)","name_zh":"胶质母细胞瘤（GBM）","page_url":"https://gliostate.com/entities/glioblastoma/","page_url_zh":"https://gliostate.com/zh/entities/glioblastoma/","api_url":"https://gliostate.com/api/entities/glioblastoma.json","via":"co-mention"},{"id":"ap-1","type":"pathway","name_en":"AP-1 transcription factor complex","name_zh":"AP-1 转录因子复合物","page_url":"https://gliostate.com/entities/ap-1/","page_url_zh":"https://gliostate.com/zh/entities/ap-1/","api_url":"https://gliostate.com/api/entities/ap-1.json","via":"co-mention"},{"id":"ac-like-state","type":"cell_state","name_en":"Astrocyte-like (AC-like) state","name_zh":"星形胶质细胞样（AC 样）状态","page_url":"https://gliostate.com/entities/ac-like-state/","page_url_zh":"https://gliostate.com/zh/entities/ac-like-state/","api_url":"https://gliostate.com/api/entities/ac-like-state.json","via":"co-mention"},{"id":"cdk4","type":"gene","name_en":"CDK4 (cyclin dependent kinase 4)","name_zh":"CDK4（细胞周期蛋白依赖性激酶 4）","page_url":"https://gliostate.com/entities/cdk4/","page_url_zh":"https://gliostate.com/zh/entities/cdk4/","api_url":"https://gliostate.com/api/entities/cdk4.json","via":"co-mention"},{"id":"crispri","type":"method","name_en":"CRISPR interference (CRISPRi)","name_zh":"CRISPR 干扰（CRISPRi）","page_url":"https://gliostate.com/entities/crispri/","page_url_zh":"https://gliostate.com/zh/entities/crispri/","api_url":"https://gliostate.com/api/entities/crispri.json","via":"co-mention"}]}