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A patient-derived GBM organoid biobank recapitulates inter- and intra-tumoral heterogeneity; Core2Edge pairs organoids with brain slices to model infiltration; organoids are used for drug screening and temozolomide-response modelling.","zh":"实验模型系统。患者来源 GBM 类器官生物库再现肿瘤间与肿瘤内异质性；Core2Edge 将类器官与脑片结合以模拟浸润；类器官被用于药物筛选与替莫唑胺反应建模。"},"externalIds":{},"modelKind":"experimental","graphNames":[],"mentions":{"items":["VC0067","VC0096","VC0097","VC0129","VC0136"],"topics":["dataset-gbm-single-cell-spatial","perturbation-gbm-therapy"]},"evidenceRefs":["VC0067","VC0096","VC0097","VC0129"],"reviewStatus":"draft","version":"0.1.0","page_url":"https://gliostate.com/entities/gbm-organoid/","page_url_zh":"https://gliostate.com/zh/entities/gbm-organoid/","api_url":"https://gliostate.com/api/entities/gbm-organoid.json","external_links":[],"source_file":"https://gliostate.com/data/entities/gbm-organoid.json","evidence_items":[{"id":"VC0067","title":"A Patient-Derived Glioblastoma Organoid Model and Biobank Recapitulates Inter- and Intra-tumoral Heterogeneity.","year":"2019","page_url":"https://gliostate.com/library/VC0067/","api_url":"https://gliostate.com/api/items/VC0067.json"},{"id":"VC0096","title":"Core2Edge: a human glioblastoma organoid-brain slice model capturing infiltration and transcriptional heterogeneity from core to single-cell dispersion.","year":"2026","page_url":"https://gliostate.com/library/VC0096/","api_url":"https://gliostate.com/api/items/VC0096.json"},{"id":"VC0097","title":"Automated and personalized glioblastoma tumor organoid drug screening platform exposes sensitivity to proteasome and HDAC inhibitors.","year":"2026","page_url":"https://gliostate.com/library/VC0097/","api_url":"https://gliostate.com/api/items/VC0097.json"},{"id":"VC0129","title":"DELPHAI, AI Agent for Predicting Drug Response and Resistance","year":"2025","page_url":"https://gliostate.com/library/VC0129/","api_url":"https://gliostate.com/api/items/VC0129.json"}],"mentioned_in_items":[{"id":"VC0067","title":"A Patient-Derived Glioblastoma Organoid Model and Biobank Recapitulates Inter- and Intra-tumoral Heterogeneity.","year":"2019","page_url":"https://gliostate.com/library/VC0067/","api_url":"https://gliostate.com/api/items/VC0067.json"},{"id":"VC0096","title":"Core2Edge: a human glioblastoma organoid-brain slice model capturing infiltration and transcriptional heterogeneity from core to single-cell dispersion.","year":"2026","page_url":"https://gliostate.com/library/VC0096/","api_url":"https://gliostate.com/api/items/VC0096.json"},{"id":"VC0097","title":"Automated and personalized glioblastoma tumor organoid drug screening platform exposes sensitivity to proteasome and HDAC inhibitors.","year":"2026","page_url":"https://gliostate.com/library/VC0097/","api_url":"https://gliostate.com/api/items/VC0097.json"},{"id":"VC0129","title":"DELPHAI, AI Agent for Predicting Drug Response and Resistance","year":"2025","page_url":"https://gliostate.com/library/VC0129/","api_url":"https://gliostate.com/api/items/VC0129.json"},{"id":"VC0136","title":"AetherCell: A generative engine for virtual cell perturbation and in vivo drug discovery","year":"2026","page_url":"https://gliostate.com/library/VC0136/","api_url":"https://gliostate.com/api/items/VC0136.json"}],"mentioned_in_topics":[{"id":"dataset-gbm-single-cell-spatial","title_en":"Glioblastoma single-cell and spatial datasets","title_zh":"胶质母细胞瘤单细胞与空间数据集","url":"https://gliostate.com/datasets/gbm-single-cell-spatial/","api_url":"https://gliostate.com/api/topics/dataset-gbm-single-cell-spatial.json"},{"id":"perturbation-gbm-therapy","title_en":"Perturbation data for glioblastoma: radiotherapy, drugs and CRISPR","title_zh":"胶质母细胞瘤扰动数据：放疗、药物与 CRISPR","url":"https://gliostate.com/perturbations/gbm-therapy-perturbations/","api_url":"https://gliostate.com/api/topics/perturbation-gbm-therapy.json"}],"relations":[{"subject":"organoid-drug-screen","subject_name_en":"Organoid drug screening","subject_name_zh":"类器官药物筛选","predicate":"associated_with","object":"gbm-organoid","object_name_en":"Patient-derived GBM organoids","object_name_zh":"患者来源 GBM 类器官","confidence":"high","evidence":[{"id":"VC0097","role":"supports","title":"Automated and personalized glioblastoma tumor organoid drug screening platform exposes sensitivity to proteasome and HDAC inhibitors.","page_url":"https://gliostate.com/library/VC0097/","api_url":"https://gliostate.com/api/items/VC0097.json"}],"note":null,"sources":[{"kind":"topic","id":"perturbation-gbm-therapy","url":"https://gliostate.com/perturbations/gbm-therapy-perturbations/","api_url":"https://gliostate.com/api/topics/perturbation-gbm-therapy.json"}]},{"subject":"delphai","subject_name_en":"DELPHAI","subject_name_zh":"DELPHAI","predicate":"associated_with","object":"gbm-organoid","object_name_en":"Patient-derived GBM organoids","object_name_zh":"患者来源 GBM 类器官","confidence":"medium","evidence":[{"id":"VC0129","role":"supports","title":"DELPHAI, AI Agent for Predicting Drug Response and Resistance","page_url":"https://gliostate.com/library/VC0129/","api_url":"https://gliostate.com/api/items/VC0129.json"}],"note":{"en":"Preprint.","zh":"预印本。"},"sources":[{"kind":"topic","id":"model-virtual-cell","url":"https://gliostate.com/models/virtual-cell/","api_url":"https://gliostate.com/api/topics/model-virtual-cell.json"},{"kind":"topic","id":"perturbation-gbm-therapy","url":"https://gliostate.com/perturbations/gbm-therapy-perturbations/","api_url":"https://gliostate.com/api/topics/perturbation-gbm-therapy.json"}]},{"subject":"temozolomide","subject_name_en":"Temozolomide (TMZ)","subject_name_zh":"替莫唑胺（TMZ）","predicate":"perturbs","object":"gbm-organoid","object_name_en":"Patient-derived GBM organoids","object_name_zh":"患者来源 GBM 类器官","confidence":"medium","evidence":[{"id":"VC0129","role":"supports","title":"DELPHAI, AI Agent for Predicting Drug Response and Resistance","page_url":"https://gliostate.com/library/VC0129/","api_url":"https://gliostate.com/api/items/VC0129.json"}],"note":{"en":"Preprint; organoid responses to temozolomide are modelled, not measured clinically.","zh":"预印本；模拟类器官对替莫唑胺的反应，并非临床测量。"},"sources":[{"kind":"topic","id":"perturbation-gbm-therapy","url":"https://gliostate.com/perturbations/gbm-therapy-perturbations/","api_url":"https://gliostate.com/api/topics/perturbation-gbm-therapy.json"}]}],"related_entities":[{"id":"organoid-drug-screen","type":"method","name_en":"Organoid drug screening","name_zh":"类器官药物筛选","page_url":"https://gliostate.com/entities/organoid-drug-screen/","page_url_zh":"https://gliostate.com/zh/entities/organoid-drug-screen/","api_url":"https://gliostate.com/api/entities/organoid-drug-screen.json","via":"relation"},{"id":"delphai","type":"model","name_en":"DELPHAI","name_zh":"DELPHAI","page_url":"https://gliostate.com/entities/delphai/","page_url_zh":"https://gliostate.com/zh/entities/delphai/","api_url":"https://gliostate.com/api/entities/delphai.json","via":"relation"},{"id":"temozolomide","type":"drug","name_en":"Temozolomide (TMZ)","name_zh":"替莫唑胺（TMZ）","page_url":"https://gliostate.com/entities/temozolomide/","page_url_zh":"https://gliostate.com/zh/entities/temozolomide/","api_url":"https://gliostate.com/api/entities/temozolomide.json","via":"relation"},{"id":"glioblastoma","type":"disease","name_en":"Glioblastoma (GBM)","name_zh":"胶质母细胞瘤（GBM）","page_url":"https://gliostate.com/entities/glioblastoma/","page_url_zh":"https://gliostate.com/zh/entities/glioblastoma/","api_url":"https://gliostate.com/api/entities/glioblastoma.json","via":"co-mention"},{"id":"perturb-seq","type":"method","name_en":"Perturb-seq","name_zh":"Perturb-seq（扰动单细胞测序）","page_url":"https://gliostate.com/entities/perturb-seq/","page_url_zh":"https://gliostate.com/zh/entities/perturb-seq/","api_url":"https://gliostate.com/api/entities/perturb-seq.json","via":"co-mention"},{"id":"gbm-organoid-biobank","type":"dataset","name_en":"Patient-derived GBM organoid biobank","name_zh":"患者来源 GBM 类器官生物库","page_url":"https://gliostate.com/entities/gbm-organoid-biobank/","page_url_zh":"https://gliostate.com/zh/entities/gbm-organoid-biobank/","api_url":"https://gliostate.com/api/entities/gbm-organoid-biobank.json","via":"co-mention"},{"id":"cellxgene-discover","type":"dataset","name_en":"CZ CELLxGENE Discover","name_zh":"CZ CELLxGENE Discover","page_url":"https://gliostate.com/entities/cellxgene-discover/","page_url_zh":"https://gliostate.com/zh/entities/cellxgene-discover/","api_url":"https://gliostate.com/api/entities/cellxgene-discover.json","via":"co-mention"},{"id":"crispri","type":"method","name_en":"CRISPR interference (CRISPRi)","name_zh":"CRISPR 干扰（CRISPRi）","page_url":"https://gliostate.com/entities/crispri/","page_url_zh":"https://gliostate.com/zh/entities/crispri/","api_url":"https://gliostate.com/api/entities/crispri.json","via":"co-mention"}]}