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In that study CDK4 amplification favours the NPC-like state.","zh":"Neftel 等描述的胶质母细胞瘤四种恶性状态之一，类似神经祖细胞；该研究中 CDK4 扩增倾向于 NPC 样状态。"},"externalIds":{},"graphNames":["NPC-like state"],"mentions":{"items":["VC0059"],"topics":["cell-state-mes-like","cell-state-npc-opc-like"]},"evidenceRefs":["VC0059"],"reviewStatus":"draft","version":"0.1.0","page_url":"https://gliostate.com/entities/npc-like-state/","page_url_zh":"https://gliostate.com/zh/entities/npc-like-state/","api_url":"https://gliostate.com/api/entities/npc-like-state.json","external_links":[],"source_file":"https://gliostate.com/data/entities/npc-like-state.json","evidence_items":[{"id":"VC0059","title":"An Integrative Model of Cellular States, Plasticity, and Genetics for Glioblastoma.","year":"2019","page_url":"https://gliostate.com/library/VC0059/","api_url":"https://gliostate.com/api/items/VC0059.json"}],"mentioned_in_items":[{"id":"VC0059","title":"An Integrative Model of Cellular States, Plasticity, and Genetics for Glioblastoma.","year":"2019","page_url":"https://gliostate.com/library/VC0059/","api_url":"https://gliostate.com/api/items/VC0059.json"}],"mentioned_in_topics":[{"id":"cell-state-mes-like","title_en":"Mesenchymal-like (MES-like) glioblastoma cell state","title_zh":"胶质母细胞瘤间充质样（MES 样）细胞状态","url":"https://gliostate.com/cell-states/mesenchymal-like/","api_url":"https://gliostate.com/api/topics/cell-state-mes-like.json"},{"id":"cell-state-npc-opc-like","title_en":"Neural-progenitor-like (NPC-like) and OPC-like glioma cell states","title_zh":"神经前体样（NPC 样）与少突前体样（OPC 样）胶质瘤细胞状态","url":"https://gliostate.com/cell-states/neural-progenitor-like-opc-like/","api_url":"https://gliostate.com/api/topics/cell-state-npc-opc-like.json"}],"relations":[{"subject":"npc-like-state","subject_name_en":"Neural-progenitor-like (NPC-like) state","subject_name_zh":"神经祖细胞样（NPC 样）状态","predicate":"transitions_to","object":"mes-like-state","object_name_en":"Mesenchymal-like (MES-like) state","object_name_zh":"间充质样（MES 样）状态","confidence":"low","evidence":[{"id":"VC0066","role":"supports","title":"Interactions between cancer cells and immune cells drive transitions to mesenchymal-like states in glioblastoma.","page_url":"https://gliostate.com/library/VC0066/","api_url":"https://gliostate.com/api/items/VC0066.json"},{"id":"VC0059","role":"supports","title":"An Integrative Model of Cellular States, Plasticity, and Genetics for Glioblastoma.","page_url":"https://gliostate.com/library/VC0059/","api_url":"https://gliostate.com/api/items/VC0059.json"}],"note":{"en":"The library states that cancer–immune interactions drive transitions toward MES-like states and that cells can move between Neftel states, but does not name the source state; applied to all three non-MES states for review.","zh":"文献库称癌-免疫相互作用驱动向 MES 样状态的转变且细胞可在 Neftel 状态间移动，但未指明起始状态；此处对三种非 MES 状态均作标注，待复核。"},"sources":[{"kind":"topic","id":"cell-state-mes-like","url":"https://gliostate.com/cell-states/mesenchymal-like/","api_url":"https://gliostate.com/api/topics/cell-state-mes-like.json"},{"kind":"topic","id":"transition-therapy-induced-plasticity","url":"https://gliostate.com/transitions/therapy-induced-plasticity/","api_url":"https://gliostate.com/api/topics/transition-therapy-induced-plasticity.json"}]},{"subject":"cdk4","subject_name_en":"CDK4 (cyclin dependent kinase 4)","subject_name_zh":"CDK4（细胞周期蛋白依赖性激酶 4）","predicate":"associated_with","object":"npc-like-state","object_name_en":"Neural-progenitor-like (NPC-like) state","object_name_zh":"神经祖细胞样（NPC 样）状态","confidence":"high","evidence":[{"id":"VC0059","role":"supports","title":"An Integrative Model of Cellular States, Plasticity, and Genetics for Glioblastoma.","page_url":"https://gliostate.com/library/VC0059/","api_url":"https://gliostate.com/api/items/VC0059.json"}],"note":null,"sources":[{"kind":"topic","id":"cell-state-npc-opc-like","url":"https://gliostate.com/cell-states/neural-progenitor-like-opc-like/","api_url":"https://gliostate.com/api/topics/cell-state-npc-opc-like.json"}]},{"subject":"neftel-meta-modules","subject_name_en":"Neftel meta-modules","subject_name_zh":"Neftel 元模块","predicate":"marks","object":"npc-like-state","object_name_en":"Neural-progenitor-like (NPC-like) state","object_name_zh":"神经祖细胞样（NPC 样）状态","confidence":"medium","evidence":[{"id":"VC0059","role":"supports","title":"An Integrative Model of Cellular States, Plasticity, and Genetics for Glioblastoma.","page_url":"https://gliostate.com/library/VC0059/","api_url":"https://gliostate.com/api/items/VC0059.json"}],"note":{"en":"Signature-score calls from the Neftel meta-modules are not ground truth; the signatures used in GlioState’s re-analysis were an unverified third-party transcription.","zh":"由 Neftel 元模块得到的特征得分判定并非真值；GlioState 再分析所用特征为未经核验的第三方转录。"},"sources":[{"kind":"topic","id":"validation-gbm-state-replication","url":"https://gliostate.com/validation/gbm-state-call-replication/","api_url":"https://gliostate.com/api/topics/validation-gbm-state-replication.json"}]}],"related_entities":[{"id":"mes-like-state","type":"cell_state","name_en":"Mesenchymal-like (MES-like) state","name_zh":"间充质样（MES 样）状态","page_url":"https://gliostate.com/entities/mes-like-state/","page_url_zh":"https://gliostate.com/zh/entities/mes-like-state/","api_url":"https://gliostate.com/api/entities/mes-like-state.json","via":"relation"},{"id":"cdk4","type":"gene","name_en":"CDK4 (cyclin dependent kinase 4)","name_zh":"CDK4（细胞周期蛋白依赖性激酶 4）","page_url":"https://gliostate.com/entities/cdk4/","page_url_zh":"https://gliostate.com/zh/entities/cdk4/","api_url":"https://gliostate.com/api/entities/cdk4.json","via":"relation"},{"id":"neftel-meta-modules","type":"method","name_en":"Neftel meta-modules","name_zh":"Neftel 元模块","page_url":"https://gliostate.com/entities/neftel-meta-modules/","page_url_zh":"https://gliostate.com/zh/entities/neftel-meta-modules/","api_url":"https://gliostate.com/api/entities/neftel-meta-modules.json","via":"relation"},{"id":"glioblastoma","type":"disease","name_en":"Glioblastoma (GBM)","name_zh":"胶质母细胞瘤（GBM）","page_url":"https://gliostate.com/entities/glioblastoma/","page_url_zh":"https://gliostate.com/zh/entities/glioblastoma/","api_url":"https://gliostate.com/api/entities/glioblastoma.json","via":"co-mention"},{"id":"neftel-four-state-framework","type":"method","name_en":"Neftel four-state framework","name_zh":"Neftel 四状态框架","page_url":"https://gliostate.com/entities/neftel-four-state-framework/","page_url_zh":"https://gliostate.com/zh/entities/neftel-four-state-framework/","api_url":"https://gliostate.com/api/entities/neftel-four-state-framework.json","via":"co-mention"},{"id":"opc-like-state","type":"cell_state","name_en":"Oligodendrocyte-progenitor-like (OPC-like) state","name_zh":"少突胶质前体细胞样（OPC 样）状态","page_url":"https://gliostate.com/entities/opc-like-state/","page_url_zh":"https://gliostate.com/zh/entities/opc-like-state/","api_url":"https://gliostate.com/api/entities/opc-like-state.json","via":"co-mention"},{"id":"pdgfra","type":"gene","name_en":"PDGFRA (platelet derived growth factor receptor alpha)","name_zh":"PDGFRA（血小板衍生生长因子受体 α）","page_url":"https://gliostate.com/entities/pdgfra/","page_url_zh":"https://gliostate.com/zh/entities/pdgfra/","api_url":"https://gliostate.com/api/entities/pdgfra.json","via":"co-mention"},{"id":"scfocal","type":"model","name_en":"scFOCAL / ISOSCELES","name_zh":"scFOCAL / ISOSCELES","page_url":"https://gliostate.com/entities/scfocal/","page_url_zh":"https://gliostate.com/zh/entities/scfocal/","api_url":"https://gliostate.com/api/entities/scfocal.json","via":"co-mention"}]}