{"id":"opc-like-state","type":"cell_state","name_en":"Oligodendrocyte-progenitor-like (OPC-like) state","name_zh":"少突胶质前体细胞样（OPC 样）状态","aliases":["OPC-like","OPC"],"description":{"en":"One of the four malignant glioblastoma states of Neftel et al., resembling oligodendrocyte progenitors; PDGFRA amplification favours it in that study. Single-cell studies of H3K27M gliomas also describe OPC-like programs.","zh":"Neftel 等描述的胶质母细胞瘤四种恶性状态之一，类似少突胶质前体细胞；该研究中 PDGFRA 扩增倾向于该状态。H3K27M 胶质瘤的单细胞研究也描述了 OPC 样程序。"},"externalIds":{},"graphNames":["OPC-like state"],"mentions":{"items":["VC0059","VC0064"],"topics":["cell-state-mes-like","cell-state-npc-opc-like","validation-gbm-state-replication"]},"evidenceRefs":["VC0059","VC0064"],"reviewStatus":"draft","version":"0.1.0","page_url":"https://gliostate.com/entities/opc-like-state/","page_url_zh":"https://gliostate.com/zh/entities/opc-like-state/","api_url":"https://gliostate.com/api/entities/opc-like-state.json","external_links":[],"source_file":"https://gliostate.com/data/entities/opc-like-state.json","evidence_items":[{"id":"VC0059","title":"An Integrative Model of Cellular States, Plasticity, and Genetics for Glioblastoma.","year":"2019","page_url":"https://gliostate.com/library/VC0059/","api_url":"https://gliostate.com/api/items/VC0059.json"},{"id":"VC0064","title":"Developmental and oncogenic programs in H3K27M gliomas dissected by single-cell RNA-seq.","year":"2018","page_url":"https://gliostate.com/library/VC0064/","api_url":"https://gliostate.com/api/items/VC0064.json"}],"mentioned_in_items":[{"id":"VC0059","title":"An Integrative Model of Cellular States, Plasticity, and Genetics for Glioblastoma.","year":"2019","page_url":"https://gliostate.com/library/VC0059/","api_url":"https://gliostate.com/api/items/VC0059.json"},{"id":"VC0064","title":"Developmental and oncogenic programs in H3K27M gliomas dissected by single-cell RNA-seq.","year":"2018","page_url":"https://gliostate.com/library/VC0064/","api_url":"https://gliostate.com/api/items/VC0064.json"}],"mentioned_in_topics":[{"id":"cell-state-mes-like","title_en":"Mesenchymal-like (MES-like) glioblastoma cell state","title_zh":"胶质母细胞瘤间充质样（MES 样）细胞状态","url":"https://gliostate.com/cell-states/mesenchymal-like/","api_url":"https://gliostate.com/api/topics/cell-state-mes-like.json"},{"id":"cell-state-npc-opc-like","title_en":"Neural-progenitor-like (NPC-like) and OPC-like glioma cell states","title_zh":"神经前体样（NPC 样）与少突前体样（OPC 样）胶质瘤细胞状态","url":"https://gliostate.com/cell-states/neural-progenitor-like-opc-like/","api_url":"https://gliostate.com/api/topics/cell-state-npc-opc-like.json"},{"id":"validation-gbm-state-replication","title_en":"Do Neftel-style GBM state calls replicate across platforms? A GlioState re-analysis (draft)","title_zh":"Neftel 式 GBM 状态判定能否跨平台复现？GlioState 再分析（初稿）","url":"https://gliostate.com/validation/gbm-state-call-replication/","api_url":"https://gliostate.com/api/topics/validation-gbm-state-replication.json"}],"relations":[{"subject":"opc-like-state","subject_name_en":"Oligodendrocyte-progenitor-like (OPC-like) state","subject_name_zh":"少突胶质前体细胞样（OPC 样）状态","predicate":"transitions_to","object":"mes-like-state","object_name_en":"Mesenchymal-like (MES-like) state","object_name_zh":"间充质样（MES 样）状态","confidence":"low","evidence":[{"id":"VC0066","role":"supports","title":"Interactions between cancer cells and immune cells drive transitions to mesenchymal-like states in glioblastoma.","page_url":"https://gliostate.com/library/VC0066/","api_url":"https://gliostate.com/api/items/VC0066.json"},{"id":"VC0059","role":"supports","title":"An Integrative Model of Cellular States, Plasticity, and Genetics for Glioblastoma.","page_url":"https://gliostate.com/library/VC0059/","api_url":"https://gliostate.com/api/items/VC0059.json"}],"note":{"en":"The library states that cancer–immune interactions drive transitions toward MES-like states and that cells can move between Neftel states, but does not name the source state; applied to all three non-MES states for review.","zh":"文献库称癌-免疫相互作用驱动向 MES 样状态的转变且细胞可在 Neftel 状态间移动，但未指明起始状态；此处对三种非 MES 状态均作标注，待复核。"},"sources":[{"kind":"topic","id":"cell-state-mes-like","url":"https://gliostate.com/cell-states/mesenchymal-like/","api_url":"https://gliostate.com/api/topics/cell-state-mes-like.json"},{"kind":"topic","id":"transition-therapy-induced-plasticity","url":"https://gliostate.com/transitions/therapy-induced-plasticity/","api_url":"https://gliostate.com/api/topics/transition-therapy-induced-plasticity.json"}]},{"subject":"pdgfra","subject_name_en":"PDGFRA (platelet derived growth factor receptor alpha)","subject_name_zh":"PDGFRA（血小板衍生生长因子受体 α）","predicate":"associated_with","object":"opc-like-state","object_name_en":"Oligodendrocyte-progenitor-like (OPC-like) state","object_name_zh":"少突胶质前体细胞样（OPC 样）状态","confidence":"high","evidence":[{"id":"VC0059","role":"supports","title":"An Integrative Model of Cellular States, Plasticity, and Genetics for Glioblastoma.","page_url":"https://gliostate.com/library/VC0059/","api_url":"https://gliostate.com/api/items/VC0059.json"}],"note":null,"sources":[{"kind":"topic","id":"cell-state-npc-opc-like","url":"https://gliostate.com/cell-states/neural-progenitor-like-opc-like/","api_url":"https://gliostate.com/api/topics/cell-state-npc-opc-like.json"}]},{"subject":"h3k27m","subject_name_en":"H3 K27M mutation","subject_name_zh":"H3 K27M 突变","predicate":"associated_with","object":"opc-like-state","object_name_en":"Oligodendrocyte-progenitor-like (OPC-like) state","object_name_zh":"少突胶质前体细胞样（OPC 样）状态","confidence":"high","evidence":[{"id":"VC0064","role":"supports","title":"Developmental and oncogenic programs in H3K27M gliomas dissected by single-cell RNA-seq.","page_url":"https://gliostate.com/library/VC0064/","api_url":"https://gliostate.com/api/items/VC0064.json"}],"note":{"en":"OPC-like programs in H3K27M gliomas; the library notes these may not be equivalent to GBM OPC-like states.","zh":"H3K27M 胶质瘤中的 OPC 样程序；文献库提示这些程序未必等同于 GBM 的 OPC 样状态。"},"sources":[{"kind":"topic","id":"cell-state-npc-opc-like","url":"https://gliostate.com/cell-states/neural-progenitor-like-opc-like/","api_url":"https://gliostate.com/api/topics/cell-state-npc-opc-like.json"}]},{"subject":"neftel-meta-modules","subject_name_en":"Neftel meta-modules","subject_name_zh":"Neftel 元模块","predicate":"marks","object":"opc-like-state","object_name_en":"Oligodendrocyte-progenitor-like (OPC-like) state","object_name_zh":"少突胶质前体细胞样（OPC 样）状态","confidence":"medium","evidence":[{"id":"VC0059","role":"supports","title":"An Integrative Model of Cellular States, Plasticity, and Genetics for Glioblastoma.","page_url":"https://gliostate.com/library/VC0059/","api_url":"https://gliostate.com/api/items/VC0059.json"}],"note":{"en":"Signature-score calls from the Neftel meta-modules are not ground truth; the signatures used in GlioState’s re-analysis were an unverified third-party transcription.","zh":"由 Neftel 元模块得到的特征得分判定并非真值；GlioState 再分析所用特征为未经核验的第三方转录。"},"sources":[{"kind":"topic","id":"validation-gbm-state-replication","url":"https://gliostate.com/validation/gbm-state-call-replication/","api_url":"https://gliostate.com/api/topics/validation-gbm-state-replication.json"}]}],"related_entities":[{"id":"mes-like-state","type":"cell_state","name_en":"Mesenchymal-like (MES-like) state","name_zh":"间充质样（MES 样）状态","page_url":"https://gliostate.com/entities/mes-like-state/","page_url_zh":"https://gliostate.com/zh/entities/mes-like-state/","api_url":"https://gliostate.com/api/entities/mes-like-state.json","via":"relation"},{"id":"pdgfra","type":"gene","name_en":"PDGFRA (platelet derived growth factor receptor alpha)","name_zh":"PDGFRA（血小板衍生生长因子受体 α）","page_url":"https://gliostate.com/entities/pdgfra/","page_url_zh":"https://gliostate.com/zh/entities/pdgfra/","api_url":"https://gliostate.com/api/entities/pdgfra.json","via":"relation"},{"id":"h3k27m","type":"gene","name_en":"H3 K27M mutation","name_zh":"H3 K27M 突变","page_url":"https://gliostate.com/entities/h3k27m/","page_url_zh":"https://gliostate.com/zh/entities/h3k27m/","api_url":"https://gliostate.com/api/entities/h3k27m.json","via":"relation"},{"id":"neftel-meta-modules","type":"method","name_en":"Neftel meta-modules","name_zh":"Neftel 元模块","page_url":"https://gliostate.com/entities/neftel-meta-modules/","page_url_zh":"https://gliostate.com/zh/entities/neftel-meta-modules/","api_url":"https://gliostate.com/api/entities/neftel-meta-modules.json","via":"relation"},{"id":"glioblastoma","type":"disease","name_en":"Glioblastoma (GBM)","name_zh":"胶质母细胞瘤（GBM）","page_url":"https://gliostate.com/entities/glioblastoma/","page_url_zh":"https://gliostate.com/zh/entities/glioblastoma/","api_url":"https://gliostate.com/api/entities/glioblastoma.json","via":"co-mention"},{"id":"neftel-four-state-framework","type":"method","name_en":"Neftel four-state framework","name_zh":"Neftel 四状态框架","page_url":"https://gliostate.com/entities/neftel-four-state-framework/","page_url_zh":"https://gliostate.com/zh/entities/neftel-four-state-framework/","api_url":"https://gliostate.com/api/entities/neftel-four-state-framework.json","via":"co-mention"},{"id":"ac-like-state","type":"cell_state","name_en":"Astrocyte-like (AC-like) state","name_zh":"星形胶质细胞样（AC 样）状态","page_url":"https://gliostate.com/entities/ac-like-state/","page_url_zh":"https://gliostate.com/zh/entities/ac-like-state/","api_url":"https://gliostate.com/api/entities/ac-like-state.json","via":"co-mention"},{"id":"npc-like-state","type":"cell_state","name_en":"Neural-progenitor-like (NPC-like) state","name_zh":"神经祖细胞样（NPC 样）状态","page_url":"https://gliostate.com/entities/npc-like-state/","page_url_zh":"https://gliostate.com/zh/entities/npc-like-state/","api_url":"https://gliostate.com/api/entities/npc-like-state.json","via":"co-mention"}]}