{"id":"pten","type":"gene","name_en":"PTEN (phosphatase and tensin homolog)","name_zh":"PTEN（磷酸酶与张力蛋白同源物）","aliases":["PTEN"],"description":{"en":"In patient-derived xenograft models, PTEN loss recruited BRD2 to MES gene promoters.","zh":"在患者来源异种移植模型中，PTEN 缺失使 BRD2 被招募至 MES 基因启动子。"},"externalIds":{"hgnc_symbol":"PTEN","hgnc_id":"HGNC:9588","uniprot":"P60484"},"graphNames":[],"mentions":{"items":[],"topics":["cell-state-mes-like"]},"evidenceRefs":["VC0095"],"reviewStatus":"draft","version":"0.1.0","page_url":"https://gliostate.com/entities/pten/","page_url_zh":"https://gliostate.com/zh/entities/pten/","api_url":"https://gliostate.com/api/entities/pten.json","external_links":[{"scheme":"HGNC","id":"HGNC:9588","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9588"},{"scheme":"UniProt","id":"P60484","url":"https://www.uniprot.org/uniprotkb/P60484/entry"}],"source_file":"https://gliostate.com/data/entities/pten.json","evidence_items":[{"id":"VC0095","title":"BRD2 bromodomain-mediated regulation of cell state plasticity modulates therapy response in glioblastoma.","year":"2025","page_url":"https://gliostate.com/library/VC0095/","api_url":"https://gliostate.com/api/items/VC0095.json"}],"mentioned_in_items":[],"mentioned_in_topics":[{"id":"cell-state-mes-like","title_en":"Mesenchymal-like (MES-like) glioblastoma cell state","title_zh":"胶质母细胞瘤间充质样（MES 样）细胞状态","url":"https://gliostate.com/cell-states/mesenchymal-like/","api_url":"https://gliostate.com/api/topics/cell-state-mes-like.json"}],"relations":[{"subject":"pten","subject_name_en":"PTEN (phosphatase and tensin homolog)","subject_name_zh":"PTEN（磷酸酶与张力蛋白同源物）","predicate":"suppresses","object":"mes-like-state","object_name_en":"Mesenchymal-like (MES-like) state","object_name_zh":"间充质样（MES 样）状态","confidence":"low","evidence":[{"id":"VC0095","role":"supports","title":"BRD2 bromodomain-mediated regulation of cell state plasticity modulates therapy response in glioblastoma.","page_url":"https://gliostate.com/library/VC0095/","api_url":"https://gliostate.com/api/items/VC0095.json"}],"note":{"en":"Inferred from loss-of-function wording only (“PTEN loss recruited BRD2 to MES gene promoters”); the library text does not state that intact PTEN suppresses the MES-like state. Needs review.","zh":"仅由功能缺失的表述推断（“PTEN 缺失使 BRD2 被招募至 MES 基因启动子”）；文献库文本并未说明完整的 PTEN 抑制 MES 样状态。需复核。"},"sources":[{"kind":"topic","id":"cell-state-mes-like","url":"https://gliostate.com/cell-states/mesenchymal-like/","api_url":"https://gliostate.com/api/topics/cell-state-mes-like.json"}]}],"related_entities":[{"id":"mes-like-state","type":"cell_state","name_en":"Mesenchymal-like (MES-like) state","name_zh":"间充质样（MES 样）状态","page_url":"https://gliostate.com/entities/mes-like-state/","page_url_zh":"https://gliostate.com/zh/entities/mes-like-state/","api_url":"https://gliostate.com/api/entities/mes-like-state.json","via":"relation"},{"id":"ac-like-state","type":"cell_state","name_en":"Astrocyte-like (AC-like) state","name_zh":"星形胶质细胞样（AC 样）状态","page_url":"https://gliostate.com/entities/ac-like-state/","page_url_zh":"https://gliostate.com/zh/entities/ac-like-state/","api_url":"https://gliostate.com/api/entities/ac-like-state.json","via":"co-mention"},{"id":"ap-1","type":"pathway","name_en":"AP-1 transcription factor complex","name_zh":"AP-1 转录因子复合物","page_url":"https://gliostate.com/entities/ap-1/","page_url_zh":"https://gliostate.com/zh/entities/ap-1/","api_url":"https://gliostate.com/api/entities/ap-1.json","via":"co-mention"},{"id":"brd2","type":"gene","name_en":"BRD2 (bromodomain containing 2)","name_zh":"BRD2（含溴结构域蛋白 2）","page_url":"https://gliostate.com/entities/brd2/","page_url_zh":"https://gliostate.com/zh/entities/brd2/","api_url":"https://gliostate.com/api/entities/brd2.json","via":"co-mention"},{"id":"cdk4","type":"gene","name_en":"CDK4 (cyclin dependent kinase 4)","name_zh":"CDK4（细胞周期蛋白依赖性激酶 4）","page_url":"https://gliostate.com/entities/cdk4/","page_url_zh":"https://gliostate.com/zh/entities/cdk4/","api_url":"https://gliostate.com/api/entities/cdk4.json","via":"co-mention"},{"id":"egfr","type":"gene","name_en":"EGFR (epidermal growth factor receptor)","name_zh":"EGFR（表皮生长因子受体）","page_url":"https://gliostate.com/entities/egfr/","page_url_zh":"https://gliostate.com/zh/entities/egfr/","api_url":"https://gliostate.com/api/entities/egfr.json","via":"co-mention"},{"id":"gbmap","type":"dataset","name_en":"GBmap","name_zh":"GBmap","page_url":"https://gliostate.com/entities/gbmap/","page_url_zh":"https://gliostate.com/zh/entities/gbmap/","api_url":"https://gliostate.com/api/entities/gbmap.json","via":"co-mention"},{"id":"glioblastoma","type":"disease","name_en":"Glioblastoma (GBM)","name_zh":"胶质母细胞瘤（GBM）","page_url":"https://gliostate.com/entities/glioblastoma/","page_url_zh":"https://gliostate.com/zh/entities/glioblastoma/","api_url":"https://gliostate.com/api/entities/glioblastoma.json","via":"co-mention"}]}