{"id":"temozolomide","type":"drug","name_en":"Temozolomide (TMZ)","name_zh":"替莫唑胺（TMZ）","aliases":["TMZ"],"description":{"en":"Chemotherapy agent used in glioblastoma. DELPHAI (preprint) models temozolomide responses in GBM organoids; temozolomide-specific single-cell perturbation data remain scarce.","zh":"用于胶质母细胞瘤的化疗药物。DELPHAI（预印本）模拟 GBM 类器官对替莫唑胺的反应；替莫唑胺特异的单细胞扰动数据仍然稀缺。"},"externalIds":{},"graphNames":["temozolomide"],"mentions":{"items":["VC0129"],"topics":["model-virtual-cell","perturbation-gbm-therapy","transition-therapy-induced-plasticity"]},"evidenceRefs":["VC0129"],"reviewStatus":"draft","version":"0.1.0","page_url":"https://gliostate.com/entities/temozolomide/","page_url_zh":"https://gliostate.com/zh/entities/temozolomide/","api_url":"https://gliostate.com/api/entities/temozolomide.json","external_links":[],"source_file":"https://gliostate.com/data/entities/temozolomide.json","evidence_items":[{"id":"VC0129","title":"DELPHAI, AI Agent for Predicting Drug Response and Resistance","year":"2025","page_url":"https://gliostate.com/library/VC0129/","api_url":"https://gliostate.com/api/items/VC0129.json"}],"mentioned_in_items":[{"id":"VC0129","title":"DELPHAI, AI Agent for Predicting Drug Response and Resistance","year":"2025","page_url":"https://gliostate.com/library/VC0129/","api_url":"https://gliostate.com/api/items/VC0129.json"}],"mentioned_in_topics":[{"id":"model-virtual-cell","title_en":"AI virtual cell models","title_zh":"AI 虚拟细胞模型","url":"https://gliostate.com/models/virtual-cell/","api_url":"https://gliostate.com/api/topics/model-virtual-cell.json"},{"id":"perturbation-gbm-therapy","title_en":"Perturbation data for glioblastoma: radiotherapy, drugs and CRISPR","title_zh":"胶质母细胞瘤扰动数据：放疗、药物与 CRISPR","url":"https://gliostate.com/perturbations/gbm-therapy-perturbations/","api_url":"https://gliostate.com/api/topics/perturbation-gbm-therapy.json"},{"id":"transition-therapy-induced-plasticity","title_en":"Therapy-induced plasticity in glioblastoma","title_zh":"胶质母细胞瘤的治疗诱导可塑性","url":"https://gliostate.com/transitions/therapy-induced-plasticity/","api_url":"https://gliostate.com/api/topics/transition-therapy-induced-plasticity.json"}],"relations":[{"subject":"temozolomide","subject_name_en":"Temozolomide (TMZ)","subject_name_zh":"替莫唑胺（TMZ）","predicate":"perturbs","object":"gbm-organoid","object_name_en":"Patient-derived GBM organoids","object_name_zh":"患者来源 GBM 类器官","confidence":"medium","evidence":[{"id":"VC0129","role":"supports","title":"DELPHAI, AI Agent for Predicting Drug Response and Resistance","page_url":"https://gliostate.com/library/VC0129/","api_url":"https://gliostate.com/api/items/VC0129.json"}],"note":{"en":"Preprint; organoid responses to temozolomide are modelled, not measured clinically.","zh":"预印本；模拟类器官对替莫唑胺的反应，并非临床测量。"},"sources":[{"kind":"topic","id":"perturbation-gbm-therapy","url":"https://gliostate.com/perturbations/gbm-therapy-perturbations/","api_url":"https://gliostate.com/api/topics/perturbation-gbm-therapy.json"}]},{"subject":"delphai","subject_name_en":"DELPHAI","subject_name_zh":"DELPHAI","predicate":"associated_with","object":"temozolomide","object_name_en":"Temozolomide (TMZ)","object_name_zh":"替莫唑胺（TMZ）","confidence":"medium","evidence":[{"id":"VC0129","role":"supports","title":"DELPHAI, AI Agent for Predicting Drug Response and Resistance","page_url":"https://gliostate.com/library/VC0129/","api_url":"https://gliostate.com/api/items/VC0129.json"}],"note":{"en":"Preprint; temozolomide responses modelled in GBM organoids.","zh":"预印本；在 GBM 类器官中模拟替莫唑胺反应。"},"sources":[{"kind":"topic","id":"model-virtual-cell","url":"https://gliostate.com/models/virtual-cell/","api_url":"https://gliostate.com/api/topics/model-virtual-cell.json"},{"kind":"topic","id":"perturbation-gbm-therapy","url":"https://gliostate.com/perturbations/gbm-therapy-perturbations/","api_url":"https://gliostate.com/api/topics/perturbation-gbm-therapy.json"},{"kind":"topic","id":"transition-therapy-induced-plasticity","url":"https://gliostate.com/transitions/therapy-induced-plasticity/","api_url":"https://gliostate.com/api/topics/transition-therapy-induced-plasticity.json"}]}],"related_entities":[{"id":"gbm-organoid","type":"model","name_en":"Patient-derived GBM organoids","name_zh":"患者来源 GBM 类器官","page_url":"https://gliostate.com/entities/gbm-organoid/","page_url_zh":"https://gliostate.com/zh/entities/gbm-organoid/","api_url":"https://gliostate.com/api/entities/gbm-organoid.json","via":"relation"},{"id":"delphai","type":"model","name_en":"DELPHAI","name_zh":"DELPHAI","page_url":"https://gliostate.com/entities/delphai/","page_url_zh":"https://gliostate.com/zh/entities/delphai/","api_url":"https://gliostate.com/api/entities/delphai.json","via":"relation"},{"id":"glioblastoma","type":"disease","name_en":"Glioblastoma (GBM)","name_zh":"胶质母细胞瘤（GBM）","page_url":"https://gliostate.com/entities/glioblastoma/","page_url_zh":"https://gliostate.com/zh/entities/glioblastoma/","api_url":"https://gliostate.com/api/entities/glioblastoma.json","via":"co-mention"},{"id":"crispri","type":"method","name_en":"CRISPR interference (CRISPRi)","name_zh":"CRISPR 干扰（CRISPRi）","page_url":"https://gliostate.com/entities/crispri/","page_url_zh":"https://gliostate.com/zh/entities/crispri/","api_url":"https://gliostate.com/api/entities/crispri.json","via":"co-mention"},{"id":"mathematical-modelling","type":"method","name_en":"Mathematical and mechanistic modelling","name_zh":"数学与机制建模","page_url":"https://gliostate.com/entities/mathematical-modelling/","page_url_zh":"https://gliostate.com/zh/entities/mathematical-modelling/","api_url":"https://gliostate.com/api/entities/mathematical-modelling.json","via":"co-mention"},{"id":"perturb-seq","type":"method","name_en":"Perturb-seq","name_zh":"Perturb-seq（扰动单细胞测序）","page_url":"https://gliostate.com/entities/perturb-seq/","page_url_zh":"https://gliostate.com/zh/entities/perturb-seq/","api_url":"https://gliostate.com/api/entities/perturb-seq.json","via":"co-mention"},{"id":"radiotherapy","type":"method","name_en":"Radiotherapy","name_zh":"放射治疗","page_url":"https://gliostate.com/entities/radiotherapy/","page_url_zh":"https://gliostate.com/zh/entities/radiotherapy/","api_url":"https://gliostate.com/api/entities/radiotherapy.json","via":"co-mention"},{"id":"scfocal","type":"model","name_en":"scFOCAL / ISOSCELES","name_zh":"scFOCAL / ISOSCELES","page_url":"https://gliostate.com/entities/scfocal/","page_url_zh":"https://gliostate.com/zh/entities/scfocal/","api_url":"https://gliostate.com/api/entities/scfocal.json","via":"co-mention"}]}