{"id":"VC0095","type":"paper","title":"BRD2 bromodomain-mediated regulation of cell state plasticity modulates therapy response in glioblastoma.","authors_or_org":"Vadla R et al.","date":"2025-11-01","year":"2025","venue":"Neuro-oncology","url":"https://doi.org/10.1093/neuonc/noaf169","doi":"10.1093/neuonc/noaf169","pmid":"40686478","brain_tumor_focus":"yes","tags":["GBM","plasticity","BRD2"],"tag_slugs":["gbm","plasticity"],"tag_labels":["GBM","Plasticity"],"tag_labels_zh":["胶质母细胞瘤","细胞可塑性"],"unmapped_tags":["BRD2"],"one_line_summary_en":"BRD2 regulates GBM cell-state plasticity and therapy response.","one_line_summary_zh":"BRD2调控GBM状态可塑性与治疗反应。","verified":"yes","verification_source":"Europe PMC","page_url":"https://gliostate.com/library/VC0095/","api_url":"https://gliostate.com/api/items/VC0095.json","sameAs":["https://doi.org/10.1093/neuonc/noaf169","https://pubmed.ncbi.nlm.nih.gov/40686478/"],"is_preprint":false,"facets":{"type":"https://gliostate.com/library/type/paper/","year":"https://gliostate.com/library/year/2025/","tags":["https://gliostate.com/library/tag/gbm/","https://gliostate.com/library/tag/plasticity/"]},"cited_by":[{"id":"cell-state-mes-like","type":"cell_state","title_en":"Mesenchymal-like (MES-like) glioblastoma cell state","title_zh":"胶质母细胞瘤间充质样（MES 样）细胞状态","url":"https://gliostate.com/cell-states/mesenchymal-like/","api_url":"https://gliostate.com/api/topics/cell-state-mes-like.json"},{"id":"perturbation-gbm-therapy","type":"perturbation","title_en":"Perturbation data for glioblastoma: radiotherapy, drugs and CRISPR","title_zh":"胶质母细胞瘤扰动数据：放疗、药物与 CRISPR","url":"https://gliostate.com/perturbations/gbm-therapy-perturbations/","api_url":"https://gliostate.com/api/topics/perturbation-gbm-therapy.json"},{"id":"transition-therapy-induced-plasticity","type":"transition","title_en":"Therapy-induced plasticity in glioblastoma","title_zh":"胶质母细胞瘤的治疗诱导可塑性","url":"https://gliostate.com/transitions/therapy-induced-plasticity/","api_url":"https://gliostate.com/api/topics/transition-therapy-induced-plasticity.json"}],"related":[{"id":"VC0066","title":"Interactions between cancer cells and immune cells drive transitions to mesenchymal-like states in glioblastoma.","shared_tags":["gbm","plasticity"],"page_url":"https://gliostate.com/library/VC0066/","api_url":"https://gliostate.com/api/items/VC0066.json"},{"id":"VC0093","title":"Spatial epigenomic niches underlie glioblastoma cell state plasticity","shared_tags":["gbm","plasticity"],"page_url":"https://gliostate.com/library/VC0093/","api_url":"https://gliostate.com/api/items/VC0093.json"},{"id":"VC0059","title":"An Integrative Model of Cellular States, Plasticity, and Genetics for Glioblastoma.","shared_tags":["gbm","plasticity"],"page_url":"https://gliostate.com/library/VC0059/","api_url":"https://gliostate.com/api/items/VC0059.json"},{"id":"VC0139","title":"Engineered regulatory states resolve context-dependent genetics in macular degeneration","shared_tags":["plasticity"],"page_url":"https://gliostate.com/library/VC0139/","api_url":"https://gliostate.com/api/items/VC0139.json"},{"id":"VC0096","title":"Core2Edge: a human glioblastoma organoid-brain slice model capturing infiltration and transcriptional heterogeneity from core to single-cell dispersion.","shared_tags":["gbm"],"page_url":"https://gliostate.com/library/VC0096/","api_url":"https://gliostate.com/api/items/VC0096.json"},{"id":"VC0097","title":"Automated and personalized glioblastoma tumor organoid drug screening platform exposes sensitivity to proteasome and HDAC inhibitors.","shared_tags":["gbm"],"page_url":"https://gliostate.com/library/VC0097/","api_url":"https://gliostate.com/api/items/VC0097.json"}]}