Engineered regulatory states resolve context-dependent genetics in macular degeneration

Norman/Dey labs (MSKCC): CRISPRa Multiome Perturb-seq of 119 TFs + dual-guide Perturb-seq of 1,225 TF pairs in RPE-1; chromatin priming predicts emergent states; Mosaic (Transformer) predicts TF-pair interaction residuals (r=0.484) and nominated a validated triple-TF combination.

Authors / organisation

Metzner E, Guruvayurappan K, Southard KM, Ardy RC, Dey KK, Norman TM.

Venue

bioRxiv

Date

2026-10-12

Type

preprint

Year

2026

DOI

10.64898/2026.10.09.758047

Verification

Crossref;PDF

PerturbationPerturb-seqMulti-omicsPlasticityTF-combinationsMosaicgenetic-interactionAMDomnigenic

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