An operational perturbation proteomics-based virtual cell model.
Sun R et al. · Nature · 2026-09-09
Nature 2026: operational perturbation-proteomics-based virtual cell model.
Tag: AI virtual cell
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PerturbLDM: conditional latent diffusion for modelling single-cell perturbation responses
Yu et al. · bioRxiv · 2026-08-12
PerturbLDM: Tahoe-100M-pretrained latent diffusion for conditional sc response generation across drug/dose/cell-line.
UniPert-G2CP bridges genetic and chemical screens from molecular representation to phenotype modeling
Li et al. · Cell · 2026-08
UniPert-G2CP: unified genetic/chemical perturbagen embeddings + CRISPR-to-drug phenotype transfer for AIVC.
Harnessing AI to Build Virtual Cells (VCHarness)
Cheng et al. · bioRxiv · 2026-04-14
VCHarness: autonomous AI coding agent that searches/refines perturbation-response model architectures for virtual cells.
AetherCell: A generative engine for virtual cell perturbation and in vivo drug discovery
Li et al. · bioRxiv · 2026-03-16
AetherCell unifies clinical RNA-seq and perturbation assays for generative response prediction and in vivo repurposing.
Towards building a World Model to simulate perturbation-induced cellular dynamics by AlphaCell
Chuai et al. · bioRxiv · 2026-03-05
AlphaCell: genome-wide virtual-cell world model with OT conditional flow matching for cross-context perturbation dynamics.
How to build the virtual cell with artificial intelligence: Priorities and opportunities.
Bunne C et al. · Cell · 2024-12-01
Landmark perspective defining the AI Virtual Cell (AIVC): multiscale, multimodal, universal representations and virtual instruments.