A Proteome-Calibrated Mechanistic Digital Twin of the Glioblastoma Astrocyte Derived from Patient Multi-Omic Data
Mayfield JD. · bioRxiv · 2026-04-23
Proteome-calibrated mechanistic digital twin of the GBM astrocyte (bioRxiv 2026).
Tag: Mechanistic & agent-based model
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Human interpretable grammar encodes multicellular systems biology models to democratize virtual cell laboratories.
Johnson JAI et al. · Cell · 2025-07-26
Human-interpretable grammar for multicellular agent-based models (PhysiCell) to democratize virtual cell labs.
Mapping the spatial architecture of glioblastoma from core to edge delineates niche-specific tumor cell states and intercellular interactions
Khan SM et al. · bioRxiv · 2025-04-04
Spatial architecture of GBM from core to edge; niche-specific states.
A method for in silico exploration of potential glioblastoma multiforme attractors using single-cell RNA sequencing.
Vieira Junior MG, de Almeida Côrtes AM, Gonçalves Carneiro FR, Carels N, Silva FABD. · Scientific reports · 2024-10-29
In silico exploration of GBM attractors from scRNA-seq (Boolean network).
A simple agent-based hybrid model to simulate the biophysics of glioblastoma multiforme cells and the concomitant evolution of the oxygen field.
Saucedo-Mora L, Sanz MÁ, Montáns FJ, Benítez JM. · Computer methods and programs in biomedicine · 2024-01-26
Agent-based hybrid model of GBM cell biophysics and treatment.
Virtual and real brain tumors: using mathematical modeling to quantify glioma growth and invasion.
Swanson KR, Bridge C, Murray JD, Alvord EC. · Journal of the neurological sciences · 2003-12-01
Swanson et al.: 'virtual and real brain tumors' — classic proliferation-invasion model.