Evidence in the library suggests that GBM cells shift state under therapy — recurrent tumors show a mesenchymal shift, and radiotherapy rewires responses to genetic perturbations in mouse models. Whether these shifts can be predicted computationally has not yet been demonstrated.文献库证据提示 GBM 细胞在治疗下会发生状态转变——复发肿瘤表现出间充质转变，小鼠模型中放疗会重塑细胞对基因扰动的反应。这些转变能否被计算预测尚未得到证明。
VC0097 Automated and personalized glioblastoma tumor organoid drug screening platform exposes sensitivity to proteasome and HDAC inhibitors. — Jungwirth G et al., NPJ precision oncology, 2026
VC0134 TumorTwin: a Python framework for patient-specific digital twins in oncology — Kapteyn et al., BMC Med Inform Decis Mak, 2026
VC0089 A longitudinal single-cell and spatial multiomic atlas of pediatric high-grade glioma. — Sussman JH et al., Cell reports. Medicine, 2026
VC0132 Drug and single-cell gene expression integration identifies sensitive and resistant glioblastoma cell populations — Suter et al., Nature Communications, 2026
VC0095 BRD2 bromodomain-mediated regulation of cell state plasticity modulates therapy response in glioblastoma. — Vadla R et al., Neuro-oncology, 2025
VC0129 · preprint · 预印本 DELPHAI, AI Agent for Predicting Drug Response and Resistance — Peng et al., preprint, 2025
VC0073 Multiscale mathematical model-informed reinforcement learning optimizes combination treatment scheduling in glioblastoma evolution. — Liu Z, Zhang J, Hong L, Nie Q, Sun X., Science advances, 2025
VC0048 Deep-learning-based gene perturbation effect prediction does not yet outperform simple linear baselines. — Ahlmann-Eltze C, Huber W, Anders S., Nature methods, 2025
VC0066 Interactions between cancer cells and immune cells drive transitions to mesenchymal-like states in glioblastoma. — Hara T et al., Cancer cell, 2025
VC0093 · preprint · 预印本 Spatial epigenomic niches underlie glioblastoma cell state plasticity — Kint S et al., bioRxiv, 2025
VC0070 In vivo perturb-seq of cancer and microenvironment cells dissects oncologic drivers and radiotherapy responses in glioblastoma. — Liu SJ et al., Genome biology, 2024
VC0069 A single-cell atlas of glioblastoma evolution under therapy reveals cell-intrinsic and cell-extrinsic therapeutic targets. — Wang L, Jung J, Babikir H, Shamardani K, Jain S, Feng X, Gupta N, Rosi S, Chang S, Raleigh D, Solomon D, Phillips JJ, Diaz AA., Nature cancer, 2022
VC0059 An Integrative Model of Cellular States, Plasticity, and Genetics for Glioblastoma. — Neftel C et al., Cell, 2019