Core2Edge: a human glioblastoma organoid-brain slice model capturing infiltration and transcriptional heterogeneity from core to single-cell dispersion.
Melhem A et al. · Nature protocols · 2026-07-28
Core2Edge：GBM类器官-脑片浸润模型。
标签：胶质母细胞瘤
共 21 条，按时间倒序。
Automated and personalized glioblastoma tumor organoid drug screening platform exposes sensitivity to proteasome and HDAC inhibitors.
Jungwirth G et al. · NPJ precision oncology · 2026-06-16
自动化个体化GBM类器官药筛平台。
A Proteome-Calibrated Mechanistic Digital Twin of the Glioblastoma Astrocyte Derived from Patient Multi-Omic Data
Mayfield JD. · bioRxiv · 2026-04-23
蛋白质组校准的GBM星形细胞机制性数字孪生（预印本）。
Anatomically aware simulation of patient-specific glioblastoma xenografts
Malik et al. · PLoS Comput Biol · 2026-01-20
基于小鼠脑解剖的患者特异性GBM异种移植生长/侵袭模型；ABC拟合；通过扰动参数模拟治疗。
Drug and single-cell gene expression integration identifies sensitive and resistant glioblastoma cell populations
Suter et al. · Nature Communications · 2026-01-07
scFOCAL/ISOSCELES：把GBM细胞状态接到L1000药签，预测状态敏感度并验证OLIG2抑制剂+Depatux-M。
BRD2 bromodomain-mediated regulation of cell state plasticity modulates therapy response in glioblastoma.
Vadla R et al. · Neuro-oncology · 2025-11-01
BRD2调控GBM状态可塑性与治疗反应。
Charting the single-cell and spatial landscape of IDH-wild-type glioblastoma with GBmap.
Ruiz-Moreno C et al. · Neuro-oncology · 2025-10-01
GBmap：IDH野生型GBM单细胞与空间参考图谱。
DELPHAI, AI Agent for Predicting Drug Response and Resistance
Peng et al. · preprint · 2025-09-17
DELPHAI：GBM类器官+TMZ的单细胞扰动预测与LLM机制解读；最优传输+PCA优于基线。
Interactions between cancer cells and immune cells drive transitions to mesenchymal-like states in glioblastoma.
Hara T et al. · Cancer cell · 2025-05-27
免疫细胞驱动GBM向间充质样状态转变。
Spatial epigenomic niches underlie glioblastoma cell state plasticity
Kint S et al. · bioRxiv · 2025-05-14
空间表观生态位决定GBM状态可塑性。
Mapping the spatial architecture of glioblastoma from core to edge delineates niche-specific tumor cell states and intercellular interactions
Khan SM et al. · bioRxiv · 2025-04-04
GBM核心到边缘的空间结构。
A method for in silico exploration of potential glioblastoma multiforme attractors using single-cell RNA sequencing.
Vieira Junior MG, de Almeida Côrtes AM, Gonçalves Carneiro FR, Carels N, Silva FABD. · Scientific reports · 2024-10-29
基于单细胞数据的GBM吸引子计算探索。
In vivo perturb-seq of cancer and microenvironment cells dissects oncologic drivers and radiotherapy responses in glioblastoma.
Liu SJ et al. · Genome biology · 2024-10-07
GBM体内Perturb-seq：解析驱动基因与放疗反应——脑肿瘤虚拟细胞的关键训练数据类型。
Hypoxia coordinates the spatial landscape of myeloid cells within glioblastoma to affect survival.
Haley MJ et al. · Science advances · 2024-05-17
缺氧协调GBM髓系细胞空间格局。
Integrative spatial analysis reveals a multi-layered organization of glioblastoma.
Greenwald AC et al. · Cell · 2024-04-22
Greenwald等：GBM多层次空间组织。
A simple agent-based hybrid model to simulate the biophysics of glioblastoma multiforme cells and the concomitant evolution of the oxygen field.
Saucedo-Mora L, Sanz MÁ, Montáns FJ, Benítez JM. · Computer methods and programs in biomedicine · 2024-01-26
GBM细胞生物物理主体模型。
A single-cell atlas of glioblastoma evolution under therapy reveals cell-intrinsic and cell-extrinsic therapeutic targets.
Wang L, Jung J, Babikir H, Shamardani K, Jain S, Feng X, Gupta N, Rosi S, Chang S, Raleigh D, Solomon D, Phillips JJ, Diaz AA. · Nature cancer · 2022-12-20
治疗下GBM演化单细胞图谱。
Spatially resolved multi-omics deciphers bidirectional tumor-host interdependence in glioblastoma.
Ravi VM et al. · Cancer cell · 2022-06-01
Ravi等：GBM空间多组学揭示肿瘤-宿主相互依存。
Single-cell RNA-seq reveals that glioblastoma recapitulates a normal neurodevelopmental hierarchy.
Couturier CP et al. · Nature communications · 2020-07-08
GBM重演神经发育层级。
A Patient-Derived Glioblastoma Organoid Model and Biobank Recapitulates Inter- and Intra-tumoral Heterogeneity.
Jacob F et al. · Cell · 2019-12-26
Jacob等：患者来源GBM类器官库。
An Integrative Model of Cellular States, Plasticity, and Genetics for Glioblastoma.
Neftel C et al. · Cell · 2019-07-18
Neftel等：GBM四种恶性细胞状态及可塑性——虚拟细胞建模的核心“状态空间”。