AP-1 transcription factor complex
Also known as: AP-1 · AP1
In 86 patient-matched primary–recurrent glioblastoma pairs, the shift to a mesenchymal phenotype at recurrence was reported to be mediated by AP-1. VC0069
Review pending Version 0.1.0 · status: draft · last expert review: not yet reviewed
Relations
| Subject | Relation | Object | Confidence | Evidence (role) |
|---|---|---|---|---|
| AP-1 transcription factor complex | promotes | Mesenchymal-like state | medium | VC0069 supports Reported as mediating the mesenchymal shift in recurrent tumors; this is an observation at recurrence and does not show whether therapy induces or selects the state. |
Appears in research topics
- Mesenchymal-like (MES-like) glioblastoma cell state (Cell states)
- Therapy-induced plasticity in glioblastoma (Transitions)
Appears in library items (1)
Items whose title, tags or one-line summary match this entity (derived from the data), plus the items cited as evidence for the description.
- VC0069 A single-cell atlas of glioblastoma evolution under therapy reveals cell-intrinsic and cell-extrinsic therapeutic targets. — Wang L, Jung J, Babikir H, Shamardani K, Jain S, Feng X, Gupta N, Rosi S, Chang S, Raleigh D, Solomon D, Phillips JJ, Diaz AA., Nature cancer, 2022
For research and education only. Not medical advice and not a recommendation of any diagnosis, treatment or product. Patients should consult their own physicians.