Patient-derived xenograft (PDX) models
Also known as: patient-derived xenograft · xenograft
Experimental model system used for the BRD2 findings (MES transition reversed by BRD2 bromodomain ablation) and as the basis of anatomy-aware simulation of patient-specific GBM xenografts. VC0095 VC0133
Review pending Version 0.1.0 · status: draft · last expert review: not yet reviewed
Relations
| Subject | Relation | Object | Confidence | Evidence (role) |
|---|---|---|---|---|
| BRD2 | validated by | Patient-derived xenograft models | high | VC0095 supports Tested in patient-derived xenografts; not shown in patients. |
Appears in research topics
- Mesenchymal-like (MES-like) glioblastoma cell state (Cell states)
Appears in library items (2)
Items whose title, tags or one-line summary match this entity (derived from the data), plus the items cited as evidence for the description.
- VC0133 Anatomically aware simulation of patient-specific glioblastoma xenografts — Malik et al., PLoS Comput Biol, 2026
- VC0095 BRD2 bromodomain-mediated regulation of cell state plasticity modulates therapy response in glioblastoma. — Vadla R et al., Neuro-oncology, 2025
For research and education only. Not medical advice and not a recommendation of any diagnosis, treatment or product. Patients should consult their own physicians.