Patient-derived GBM organoids
Also known as: GBM organoid · GBO
Experimental model system. A patient-derived GBM organoid biobank recapitulates inter- and intra-tumoral heterogeneity; Core2Edge pairs organoids with brain slices to model infiltration; organoids are used for drug screening and temozolomide-response modelling. VC0067 VC0096 VC0097 VC0129 · preprint
Review pending Version 0.1.0 · status: draft · last expert review: not yet reviewed
Relations
| Subject | Relation | Object | Confidence | Evidence (role) |
|---|---|---|---|---|
| Organoid drug screening | associated with | Patient-derived GBM organoids | high | VC0097 supports |
| DELPHAI | associated with | Patient-derived GBM organoids | medium | VC0129 · preprint supports Preprint. |
| Temozolomide | perturbs | Patient-derived GBM organoids | medium | VC0129 · preprint supports Preprint; organoid responses to temozolomide are modelled, not measured clinically. |
Appears in research topics
Appears in library items (5)
Items whose title, tags or one-line summary match this entity (derived from the data), plus the items cited as evidence for the description.
- VC0096 Core2Edge: a human glioblastoma organoid-brain slice model capturing infiltration and transcriptional heterogeneity from core to single-cell dispersion. — Melhem A et al., Nature protocols, 2026
- VC0097 Automated and personalized glioblastoma tumor organoid drug screening platform exposes sensitivity to proteasome and HDAC inhibitors. — Jungwirth G et al., NPJ precision oncology, 2026
- VC0136 · preprint AetherCell: A generative engine for virtual cell perturbation and in vivo drug discovery — Li et al., bioRxiv, 2026
- VC0129 · preprint DELPHAI, AI Agent for Predicting Drug Response and Resistance — Peng et al., preprint, 2025
- VC0067 A Patient-Derived Glioblastoma Organoid Model and Biobank Recapitulates Inter- and Intra-tumoral Heterogeneity. — Jacob F et al., Cell, 2019
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