Neural-progenitor-like (NPC-like) state
Also known as: NPC-like · NPC
One of the four malignant glioblastoma states of Neftel et al., resembling neural progenitors. In that study CDK4 amplification favours the NPC-like state. VC0059
Review pending Version 0.1.0 · status: draft · last expert review: not yet reviewed
Relations
| Subject | Relation | Object | Confidence | Evidence (role) |
|---|---|---|---|---|
| Neural-progenitor-like state | transitions to | Mesenchymal-like state | low | VC0066 supports VC0059 supports The library states that cancer–immune interactions drive transitions toward MES-like states and that cells can move between Neftel states, but does not name the source state; applied to all three non-MES states for review. |
| CDK4 | associated with | Neural-progenitor-like state | high | VC0059 supports |
| Neftel meta-modules | marks | Neural-progenitor-like state | medium | VC0059 supports Signature-score calls from the Neftel meta-modules are not ground truth; the signatures used in GlioState’s re-analysis were an unverified third-party transcription. |
Appears in research topics
Appears in library items (1)
Items whose title, tags or one-line summary match this entity (derived from the data), plus the items cited as evidence for the description.
- VC0059 An Integrative Model of Cellular States, Plasticity, and Genetics for Glioblastoma. — Neftel C et al., Cell, 2019
For research and education only. Not medical advice and not a recommendation of any diagnosis, treatment or product. Patients should consult their own physicians.