Oligodendrocyte-progenitor-like (OPC-like) state
Also known as: OPC-like · OPC
One of the four malignant glioblastoma states of Neftel et al., resembling oligodendrocyte progenitors; PDGFRA amplification favours it in that study. Single-cell studies of H3K27M gliomas also describe OPC-like programs. VC0059 VC0064
Review pending Version 0.1.0 · status: draft · last expert review: not yet reviewed
Relations
| Subject | Relation | Object | Confidence | Evidence (role) |
|---|---|---|---|---|
| Oligodendrocyte-progenitor-like state | transitions to | Mesenchymal-like state | low | VC0066 supports VC0059 supports The library states that cancer–immune interactions drive transitions toward MES-like states and that cells can move between Neftel states, but does not name the source state; applied to all three non-MES states for review. |
| PDGFRA | associated with | Oligodendrocyte-progenitor-like state | high | VC0059 supports |
| H3 K27M mutation | associated with | Oligodendrocyte-progenitor-like state | high | VC0064 supports OPC-like programs in H3K27M gliomas; the library notes these may not be equivalent to GBM OPC-like states. |
| Neftel meta-modules | marks | Oligodendrocyte-progenitor-like state | medium | VC0059 supports Signature-score calls from the Neftel meta-modules are not ground truth; the signatures used in GlioState’s re-analysis were an unverified third-party transcription. |
Appears in research topics
Appears in library items (2)
Items whose title, tags or one-line summary match this entity (derived from the data), plus the items cited as evidence for the description.
- VC0059 An Integrative Model of Cellular States, Plasticity, and Genetics for Glioblastoma. — Neftel C et al., Cell, 2019
- VC0064 Developmental and oncogenic programs in H3K27M gliomas dissected by single-cell RNA-seq. — Filbin MG et al., Science (New York, N.Y.), 2018
For research and education only. Not medical advice and not a recommendation of any diagnosis, treatment or product. Patients should consult their own physicians.