PTEN (phosphatase and tensin homolog)
Also known as: PTEN
In patient-derived xenograft models, PTEN loss recruited BRD2 to MES gene promoters. VC0095
Review pending Version 0.1.0 · status: draft · last expert review: not yet reviewed
External identifiers
- HGNC symbol
- PTEN
- HGNC
- HGNC:9588
- UniProt
- P60484
Identifiers were checked against the public registry (HGNC, UniProt, MONDO via EBI OLS, NCBI GEO) and are listed only when certain.
Relations
| Subject | Relation | Object | Confidence | Evidence (role) |
|---|---|---|---|---|
| PTEN | suppresses | Mesenchymal-like state | low | VC0095 supports Inferred from loss-of-function wording only (“PTEN loss recruited BRD2 to MES gene promoters”); the library text does not state that intact PTEN suppresses the MES-like state. Needs review. |
Appears in research topics
- Mesenchymal-like (MES-like) glioblastoma cell state (Cell states)
Appears in library items (1)
Items whose title, tags or one-line summary match this entity (derived from the data), plus the items cited as evidence for the description.
- VC0095 BRD2 bromodomain-mediated regulation of cell state plasticity modulates therapy response in glioblastoma. — Vadla R et al., Neuro-oncology, 2025
For research and education only. Not medical advice and not a recommendation of any diagnosis, treatment or product. Patients should consult their own physicians.